Role of the Transcription Factor Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier

Medicine, Neurology, Life Sciences,
Nrf2   blood-brain barrier   inflammation   oxidative stress   neurological disorders   tight junction   phytochemicals  

The Role of Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier Academic Background The blood-brain barrier (BBB) is a crucial barrier between the central nervous system (CNS) and the peripheral blood circulation, composed of endothelial cells, pericytes, smooth muscle cells, astrocytes, and neurons. The primary function of the BBB is to s...

Neuroprotective Effects of Sinomenine on Experimental Autoimmune Encephalomyelitis via Anti-inflammatory and Nrf2-dependent Anti-oxidative Stress Activity

Medicine, Neurology,
Sinomenine   Experimental Autoimmune Encephalomyelitis   Multiple Sclerosis   Neuroinflammation   Oxidative Stress   Nrf2  

Research Background on Multiple Sclerosis and Central Nervous System Inflammation Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS), often accompanied by chronic inflammation, leading to oligodendrocyte loss, activation of brain-resident immune cells, blood-brain barrier disruption, extensive demyelin...