Novel Endocytosis Inhibitors Block Entry of HIV-1 Tat into Neural Cells

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Neurology, Life Sciences, Biochemistry, Immunology,
HIV-1 Tat   endocytosis inhibitors   oxidative stress   DNA damage   neural cells  

Novel Endocytosis Inhibitors Block HIV-1 Tat Protein Entry into Neural Cells Academic Background HIV-1 (human immunodeficiency virus type 1) infection not only leads to immune system exhaustion but is also closely associated with HIV-associated neurocognitive disorders (HAND). Although combined antiretroviral therapy (cART) has significantly improv...

Macrophage Membrane-Camouflaged Nanozymes for Combating Oxidative Stress-Microvascular Perfusion Negative Feedback in Ischemia-Reperfusion Induced Acute Kidney Injury

Chemistry, Nanoscience, Medicine, Nephrology, Life Sciences, Biochemistry, Bioengineering, Immunology,
acute kidney injury   macrophage membrane   nanozymes   oxidative stress   microvascular perfusion   renal ischemia-reperfusion   anti-inflammatory therapy  

Innovative Research Report on Intravenous Macrophage Membrane-Camouflaged Nanozymes for Acute Kidney Injury Targeted Therapy Background Introduction Acute kidney injury (AKI) is a severe clinical syndrome characterized by a rapid decline in renal function and is closely associated with high morbidity and mortality. Statistics show that the incidenc...

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain through Scavenging ROS and Reducing Inflammation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
mitochondria   anti-inflammation   neuropathic pain   reactive oxygen species   bimetallic nanozymes   oxidative stress   signaling pathways  

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...

Recovery from Spreading Depolarization is Slowed by Aging and Accelerated by Antioxidant Treatment in Locusts

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
spreading depolarization   aging   antioxidant   locusts   neural circuits   oxidative stress   Na+/K+-ATPase  

The Impact of Aging and Antioxidants on the Recovery from Spreading Depolarization in Locusts Academic Background Spreading Depolarization (SD) is a phenomenon that temporarily shuts down neural processing in both mammals and insects. In humans, SD is associated with various pathological states, such as migraine aura and neuronal death following tr...

Isorhamnetin Ameliorates Dopaminergic Neuronal Damage via Targeting FOSL1 to Activate AKT/mTOR in 6-OHDA-Induced SH-SY5Y Cells

Medicine, Neurology, Life Sciences,
Isorhamnetin   FOSL1   AKT/mTOR pathway   6-OHDA   Parkinson's disease   oxidative stress   apoptosis  

Isorhamnetin Ameliorates 6-OHDA-Induced SH-SY5Y Cell Damage by Targeting FosL1 to Activate the Akt/mTOR Pathway Academic Background Parkinson’s Disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia Nigra Pars Compacta (SNpc). This neuronal loss is closely associated with mitochondri...

Relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats

Medicine, Neurology, Neurosurgery,
oxidative stress   neuronal apoptosis   relaxin-2   ERK-nNOS-NO pathway   germinal matrix hemorrhage   rat model   neuroprotection  

rh-relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats Academic Background Germinal Matrix Hemorrhage (GMH) is one of the most common neurological disorders in newborns, particularly in preterm infants, and is a major cause of brain injury. GMH not only triggers acute inf...

Role of the Transcription Factor Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier

Medicine, Neurology, Life Sciences,
Nrf2   blood-brain barrier   inflammation   oxidative stress   neurological disorders   tight junction   phytochemicals  

The Role of Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier Academic Background The blood-brain barrier (BBB) is a crucial barrier between the central nervous system (CNS) and the peripheral blood circulation, composed of endothelial cells, pericytes, smooth muscle cells, astrocytes, and neurons. The primary function of the BBB is to s...

PRDX5 and PRDX6 Translocation and Oligomerization in Bull Sperm: A Response to Cryopreservation-Induced Oxidative Stress

Medicine, Obstetrics and Gynecology, Life Sciences, Cell Biology, Biochemistry, Immunology,
bull sperm   PRDX5   PRDX6   oxidative stress   cryopreservation   antioxidant proteins   sperm quality  

PRDX5 and PRDX6 in Oxidative Stress Response During Cryopreservation of Bull Sperm Academic Background Cryopreservation is a critical step in animal breeding and assisted reproductive technologies, particularly in the preservation of bull sperm. However, oxidative stress generated during cryopreservation significantly reduces sperm quality, leading...

Skin-Permeable Gold Nanoparticles with Azelamide Monoethanolamine Modifications Ameliorate Inflammatory Skin Diseases

Chemistry, Nanoscience, Medicinal Chemistry, Materials Science, Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
gold nanoparticles   azelamide monoethanolamine   skin inflammation   topical therapeutics   oxidative stress   matrix metalloproteinase   superoxide dismutase  

Report on the Academic Paper Inflammatory skin diseases, such as psoriasis and rosacea, are common chronic skin conditions worldwide, significantly impacting patients’ quality of life. Traditional topical drug delivery methods, while simple and non-invasive, suffer from poor skin penetration and long-term side effects. Therefore, developing an effe...