Background Introduction Sepsis is a life-threatening multiple organ dysfunction syndrome caused by uncontrolled infection in the host, and is one of the leading causes of death in intensive care units. It is reported that there are approximately 189 adult sepsis hospitalization cases per 100,000 person-years, with a mortality rate of 26.7%. Sepsis-...
Research Reveals Gender-Specific Epigenetic Regulatory Mechanisms in Neuroinflammation, Injury, and Recovery Background Ischemic stroke is one of the leading causes of death and disability worldwide. Due to limited understanding of its linked disease mechanisms, current treatments for alleviating acute ischemic brain injury are very limited. Recent...
Mechanism Study of Circular RNA-GRIN2B Inhibiting Neuropathic Pain Background Introduction Neuropathic pain is a persistent pain caused by damage to the somatic sensory nervous system, with its etiology not yet fully understood and clinical treatment facing many difficulties. Given the complexity of neuropathic pain, there is an urgent need to reve...
Study on MERTK Reducing Blood-Spinal Cord Barrier Permeability after Spinal Cord Injury via RhoA/ROCK1/p-MLC Pathway Spinal Cord Injury (SCI) is a central nervous system disease caused by trauma, inflammation, tumors, or other pathological reasons, resulting in sensory, motor, and autonomic nervous system dysfunction in patients, imposing a heavy b...
Research on the Effects of Amorfrutin B on Human Microglia under Hypoxia/Ischemia Conditions: Anti-inflammatory Action, Proliferation Potential, and Mitochondrial State Based on the PPARγ Pathway Research Background Hypoxia/ischemia is a major cause of brain injury in both neonatal and adult populations. Perinatal asphyxia and ischemic stroke are l...
β-Sitosterol Alleviates Neuropathic Pain by Inhibiting the TLR4/NF-κB Signaling Pathway Background Neuropathic pain is a common and difficult-to-treat chronic pain condition in clinical practice, with complex and not fully understood etiology. Research has shown that neuroinflammation is one of the main causes of chronic neuropathic pain. Microglia...
The Gender-Dependent Effects of Carbohydrate Sources and Quantity on Caspase-1 Activity in the Central Nervous System of Mice Research Background With the global intensification of aging, the incidence of cognitive impairments and dementia is rapidly increasing, with Alzheimer’s disease being the most common form of senile dementia. Studies have sh...
The Role of Microglia in Neuroinflammation: Metabolic and Gender Differences in Aging Research Background Aging is a major risk factor for neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease. Even healthy aging is accompanied by a decline in cognitive function. Previous research has indicated that microglia undergo s...
Radiation Retinopathy Research Report Radiation Retinopathy (RR) is a common side effect following radiation therapy (such as brachytherapy or proton beam therapy) in ophthalmic tumor treatments. RR presents as delayed and progressive microvascular alterations, ischemia, and macular edema, which may ultimately lead to vision loss, neovascular glauc...
Inhibition of S6K Reduces Age-Related Inflammation and Extends Lifespan through the Endosomal-Lysosomal System Research Background and Problem Description As organisms age, chronic low-grade inflammation (inflammaging) and declined immune function (immunosenescence) become important pathological foundations of many diseases in the elderly, such as ...