Parkinson’s Disease Mouse Model: IL-10 Gene Delivery Inhibits Neuroinflammation and Neurodegeneration As research into the pathogenesis of Parkinson’s Disease (PD) deepens, the role of neuroinflammation in PD is gradually being revealed. This study by Simone Bido and his team, published in “Science Translational Medicine”, explores the effects of t...
Accumulation of Lipid Droplets in Microglia is Regulated by Neuronal AMPK Background and Research Question Alzheimer’s Disease (AD) is a common type of dementia characterized by neurofibrillary tangles and β-amyloid plaques. However, beyond these classical pathologies, changes in lipid metabolism are increasingly recognized as closely associated wi...
Research Background on Multiple Sclerosis and Central Nervous System Inflammation Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS), often accompanied by chronic inflammation, leading to oligodendrocyte loss, activation of brain-resident immune cells, blood-brain barrier disruption, extensive demyelin...
Key Mediator Akap8l in Microglia for Diabetes-Associated Cognitive Impairment: Functions via Autophagy Inhibition and Neuroinflammation Academic Background In recent years, diabetes-associated cognitive impairment (DACI) has received increasing attention. It not only poses a threat to the self-management capabilities of diabetic patients but also i...
Study on the Role of Gut Microbiota in White Matter Repair after Traumatic Brain Injury - Analysis of “Journal of Neuroinflammation” Introduction Every year, around 1.7 million people in the United States experience traumatic brain injury (TBI), with over 5 million facing disability issues related to TBI. These non-fatal TBIs are estimated to incur...
HSV-1 Infection Accelerates the Progression of Alzheimer’s Disease: Through the Regulation of Microglial Phagocytosis and Activation of the NLRP3 Pathway Research Background With the intensification of global aging, Alzheimer’s Disease (AD) has become a neurodegenerative disease affecting millions of people. In recent years, an increasing number of...
Research Review: Treating Traumatic Brain Injury through Selective Inhibition of IL-6 Pathway Background Traumatic brain injury (TBI) is one of the leading causes of long-term neurological damage and death globally, with no effective disease-modifying treatments currently available. TBI patients often suffer from cognitive, behavioral, and sensory ...
Characterization of Extracellular Vesicles from Spinal Cord Tissue in Experimental Autoimmune Encephalomyelitis Introduction Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS), and the etiology and methods for predicting disease progression are still under investigation. Experimental autoimmune encephalom...
Nanopolymer Targeting NF-κB and NLRP3 Reduces Neuroinflammation and Enhances Cognitive Function in Aging and Tauopathy Research Background Aging is a major risk factor for cognitive decline and most neurodegenerative diseases, such as Alzheimer’s disease (AD). These cognitive declines are closely related to the pathological aggregation of Tau prote...
Key Research on the Role of Macrophages in Peripheral Nerve Regeneration Background and Research Objectives Since the 1990s, research has shown that macrophages play a promoting role in peripheral nerve regeneration, and are particularly important in the conditioning lesion (CL) response. After sciatic nerve injury, macrophages accumulate at the in...