Selective Abrogation of S6K2 Identifies Lipid Homeostasis as a Survival Vulnerability in MAPK Inhibitor–Resistant NRAS-Mutant Melanoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
NRAS-mutant melanoma   MAPK inhibitor resistance   lipid metabolism   S6K2   PPARα  

Academic Background NRAS-mutant (NRASmut) melanoma is a highly aggressive tumor type, accounting for nearly 30% of all melanoma cases. NRAS is an oncogene that persistently activates the mitogen-activated protein kinase (MAPK) signaling pathway, which plays a critical role in melanoma development. However, despite extensive research on MAPK pathway...

A 5:2 Intermittent Fasting Regimen Ameliorates NASH and Fibrosis and Blunts HCC Development

Medicine, Hepatobiliary System, Endocrinology, Oncology, Life Sciences, Biochemistry,
Fasting Regimen   NASH   Liver Fibrosis   Hepatocellular Carcinoma   PPARα   PCK1  

New Scientific Discovery: The 5:2 Intermittent Fasting Regimen Improves Non-Alcoholic Steatohepatitis and Reduces Hepatocellular Carcinoma Occurrence Research Background and Problem Statement Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, with its prevalence increasing alongside rising obesity rates. N...