Proteostasis and Lysosomal Repair Deficits in Transdifferentiated Neurons of Alzheimer’s Disease

Medicine, Neurology, Life Sciences, Cell Biology,
Alzheimer’s Disease   Transdifferentiated Neurons   Proteostasis   Lysosomal Repair   Ageing   Inflammation   Cell Death  

Academic Background Alzheimer’s disease (AD) is the most common neurodegenerative disorder among the elderly, characterized by the pathological features of amyloid-beta (Aβ) deposits and hyperphosphorylated tau protein. Although aging is the most prominent risk factor for AD, the cellular mechanisms linking the decline in neuronal proteostasis to t...

Ciliopathies: Undocking of an Extensive Ciliary Network Induces Proteostasis and Cell Fate Switching Resulting in Severe Primary Ciliary Dyskinesia

Medicine, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Genetics,
Primary Ciliary Dyskinesia   Ciliary Network   Proteostasis   Cell Fate Switching   Gene Therapy  

Research on Ciliary Diseases: The Role of CCDC39/CCDC40 Heterodimer in Primary Ciliary Dyskinesia Academic Background Primary Ciliary Dyskinesia (PCD) is a rare monogenic disorder characterized by chronic respiratory infections, infertility, and organ laterality defects. Although more than 50 genes associated with PCD have been identified, mutation...