Histone Demethylases in Autophagy and Inflammation

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Histone Demethylases   Autophagy   Inflammation   Epigenetics   Cell Signaling  

The Role of Histone Demethylases in Autophagy and Inflammation Background Introduction Autophagy is an essential lysosomal degradation process in eukaryotic cells, playing a critical role in cellular component renewal and homeostasis maintenance. Dysregulation of autophagy is associated with various diseases, including cancer, inflammatory diseases...

Evaluation of the Redox Alteration in Duchenne Muscular Dystrophy Model Mice Using In Vivo DNP-MRI

Medicine, Neurology, Medical Imaging,
Duchenne Muscular Dystrophy   Redox Status   In Vivo DNP-MRI   Inflammation   Mitochondrial Function  

Academic Background Duchenne Muscular Dystrophy (DMD) is a genetic muscular disorder and the most common type of muscular dystrophy in Japan. DMD is caused by a mutation in the dystrophin gene on the X chromosome, leading to the absence or defect of the dystrophin protein in muscle fibers. This results in a cascade of events, including increased mu...

Inflammation-Induced Epigenetic Imprinting Regulates Intestinal Stem Cells

Medicine, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Inflammation   Epigenetics   Intestinal stem cells   Metabolic changes   Regeneration capacity  

Inflammation-Induced Epigenetic Imprinting and Intestinal Stem Cell Regulation In recent years, the scientific community has shown immense interest in the “memory” capabilities of non-immune cells, particularly the phenomenon where specific stem cells in adult tissues develop memory after undergoing inflammation, influencing their functionality. Ho...

Myeloid Beta-Arrestin 2 Depletion Alleviates Metabolic Dysfunction-Associated Steatohepatitis through Metabolic Reprogramming of Macrophages

Medicine, Hepatobiliary System, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Myeloid Beta-Arrestin 2   Metabolic Reprogramming   Macrophages   Steatohepatitis   Inflammation  

The Loss of β-arrestin 2 in Hepatic Macrophages Alleviates Metabolic Dysfunction-associated Steatohepatitis — Through Metabolic Reprogramming of Macrophages Background and Motivation Metabolic dysfunction-associated fatty liver disease (MASLD) is a globally prevalent health issue, affecting approximately 25% of the population. This disease includes...

The Roles of RhoA/ROCK/NF-κB Pathway in Microglia Polarization Following Ischemic Stroke

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Ischemic Stroke   RhoA/ROCK Pathway   NF-κB   Microglia   Immune Response   Brain Injury   Inflammation  

Overview of the Role of RhoA/ROCK/NF-κB Pathway in Microglial Polarization after Ischemic Stroke In recent years, ischemic stroke has become one of the leading causes of death and disability worldwide. However, effective treatments for ischemic stroke are still lacking. Studies have shown that microglia, as resident macrophages in the central nervo...

Targeting Dysregulated Phago-/Auto-Lysosomes in Sertoli Cells to Ameliorate Late-Onset Hypogonadism

Medicine, Basic Medical Sciences, Medical Laboratory Science, Geriatrics, Urology, Life Sciences, Biochemistry,
Late-Onset Hypogonadism   Sertoli Cells   Lysosomes   Aging   Single-Cell RNA Sequencing   Lipid Metabolism   Inflammation  

Research Background This study focuses on late-onset hypogonadism (LOH), aiming to uncover the mechanisms associated with age-related testicular function deviations, such as LOH, which are not yet fully understood. Utilizing single-cell RNA sequencing technology, the study analyzed the testicles of humans with LOH to identify supporting cells (SCs)...