Academic Background Doxorubicin (Dox) is an anthracycline drug widely used in the treatment of tumors, but it exhibits dose-dependent cardiotoxicity, potentially leading to cardiomyopathy and heart failure. Despite its significant anticancer effects, the cardiotoxicity of Dox limits its clinical application. Currently, Dexrazoxane is the only FDA-a...

Study on Congenital Immune Dysfunction in Cystic Fibrosis Research Background Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, primarily affecting the lungs and digestive system. One of the major problems faced by CF patients is recurrent infections and inflammatio...

DNA Hypomethylation-Mediated Upregulation of GADD45B Facilitates Airway Inflammation and Epithelial Cell Senescence in COPD Academic Background Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease characterized by chronic airway inflammation and irreversible airflow limitation, and it is one of the leading causes of death worldwi...

Prognostic Value of the CONUT Score in Immune Checkpoint Inhibitor Therapy for Metastatic Malignant Melanoma Academic Background The incidence of malignant melanoma (MM) is increasing annually, with approximately 20% of patients progressing to advanced or metastatic melanoma. Immune checkpoint inhibitors (ICIs) have significantly transformed the tr...

Exploring the Direct and Indirect Immunomodulatory Effects of Acarbose on Obesity-Associated Chronic Inflammation Academic Background With the global prevalence of obesity, related metabolic syndromes such as insulin resistance (IR), type 2 diabetes, cardiovascular diseases, and fatty liver disease have become major threats to human health. These c...

The Role of Histone Demethylases in Autophagy and Inflammation Background Introduction Autophagy is an essential lysosomal degradation process in eukaryotic cells, playing a critical role in cellular component renewal and homeostasis maintenance. Dysregulation of autophagy is associated with various diseases, including cancer, inflammatory diseases...

Academic Background Duchenne Muscular Dystrophy (DMD) is a genetic muscular disorder and the most common type of muscular dystrophy in Japan. DMD is caused by a mutation in the dystrophin gene on the X chromosome, leading to the absence or defect of the dystrophin protein in muscle fibers. This results in a cascade of events, including increased mu...

Inflammation-Induced Epigenetic Imprinting and Intestinal Stem Cell Regulation In recent years, the scientific community has shown immense interest in the “memory” capabilities of non-immune cells, particularly the phenomenon where specific stem cells in adult tissues develop memory after undergoing inflammation, influencing their functionality. Ho...

The Loss of β-arrestin 2 in Hepatic Macrophages Alleviates Metabolic Dysfunction-associated Steatohepatitis — Through Metabolic Reprogramming of Macrophages Background and Motivation Metabolic dysfunction-associated fatty liver disease (MASLD) is a globally prevalent health issue, affecting approximately 25% of the population. This disease includes...

Overview of the Role of RhoA/ROCK/NF-κB Pathway in Microglial Polarization after Ischemic Stroke In recent years, ischemic stroke has become one of the leading causes of death and disability worldwide. However, effective treatments for ischemic stroke are still lacking. Studies have shown that microglia, as resident macrophages in the central nervo...