A TBX2-Driven Signaling Switch from Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

Academic Background and Problem Statement Prostate Cancer (PCA) is one of the most common malignancies in men, particularly in advanced stages, where patients typically receive Androgen Deprivation Therapy (ADT) as the standard treatment. However, despite initial treatment efficacy, patients eventually develop Castration-Resistant Prostate Cancer (...