Clinical Significance of Stratifying Prostate Cancer Patients Through Specific Circulating Genes Academic Background Prostate Cancer (PCA) is the most common cancer among men in North America and a leading cause of cancer-related mortality. Although many patients are diagnosed with organ-confined disease, 25-35% experience recurrence after curative...

Prostate Cancer Cell Function Assessments Reveal Differences Between Gedatolisib and Single-Node PI3K/AKT/mTOR Inhibitors Academic Background Prostate cancer (PC) is one of the most common cancers among men worldwide, particularly in advanced stages where patients often develop resistance to androgen deprivation therapy (ADT), progressing to castra...

Academic Background and Problem Statement Prostate Cancer (PCA) is one of the most common malignancies in men, particularly in advanced stages, where patients typically receive Androgen Deprivation Therapy (ADT) as the standard treatment. However, despite initial treatment efficacy, patients eventually develop Castration-Resistant Prostate Cancer (...

Academic Background Prostate cancer is one of the most common cancers in men worldwide, particularly in Western countries. Despite advances in early diagnosis and treatment significantly improving survival rates, cancer recurrence remains a major clinical challenge. This is particularly true for patients with high-risk nonmetastatic hormone-sensiti...

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis via the RACK1 Signaling Axis Academic Background Prostate cancer (PCA) is a prevalent cancer among men and the second leading cause of cancer-related deaths. While early-stage prostate cancer can be treated with surgery or radiotherapy, approximately one-third...

Study on a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer on Active Surveillance Academic Background Prostate cancer is one of the most common cancers among men globally, particularly for those with low- and intermediate-risk prostate cancer, where active surveillance (AS) has become the preferred management strate...

MRI-Guided Micro-US Transperineal Focal Laser Ablation for Localized Prostate Cancer: A 1-Year Follow-Up Study Academic Background Prostate cancer (PCA) is one of the most common malignancies among men worldwide. With the widespread adoption of prostate-specific antigen (PSA) screening, the diagnosis of low-risk prostate cancer has significantly in...

Study on the Role of Coagulation Factor X in Anti-androgen Resistance in Prostate Cancer Research Background Prostate cancer (PCa) is the second most common cancer in men worldwide and is one of the leading causes of cancer-related deaths. The occurrence and progression of prostate cancer are highly dependent on the androgen receptor (AR) signaling...

Therapeutic Potential of Synergistic Targeted Inhibition of HSP90AB1 and PARP1 in Prostate Cancer Cells: A Review of Celastrol and Olaparib Combination Therapy Background Prostate Cancer (PCA) is one of the most common malignancies among men worldwide, with its incidence continually rising in recent years, making early screening and treatment cruci...

Academic Report for the Paper Titled “Prospective Study of Homologous Recombination Repair Gene Mutation Prevalence in Patients with Advanced Prostate Cancer from Latin America: Challenges and Future Approaches” Background Prostate cancer is one of the most common cancers among men in Latin America and the Caribbean (LAC). According to the 2020 Glo...