Academic Background and Problem Statement Prostate Cancer (PCA) is one of the most common malignancies in men, particularly in advanced stages, where patients typically receive Androgen Deprivation Therapy (ADT) as the standard treatment. However, despite initial treatment efficacy, patients eventually develop Castration-Resistant Prostate Cancer (...

Research Targeting Glucocorticoid Receptor-CCR8 Axis Mediated Bone Marrow T Cell Sequestration to Enhance Anti-tumor T Cell Infiltration in Intracranial Cancer Background Brain tumors, especially glioblastomas (GBMs), show significant resistance to immune checkpoint blockade therapy, partly due to limited T cell infiltration into tumors. GBMs accou...