Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice

Medicine, Cardiovascular System,
aortic aneurysm   endothelial cells   heterogeneity   site-specificity   RNA-seq  

Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice Academic Background Aortic aneurysm (AA) is characterized by pathological dilation at specific predilection sites of the vessel, potentially leading to life-threatening vascular rupture. Aortic aneurysms typic...

Oscillatory Contractile Forces Refine Endothelial Cell-Cell Interactions for Continuous Lumen Formation Governed by Heg1/CCM1

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biophysics,
oscillatory contractile forces   endothelial cells   Heg1   CCM1   lumen formation   cell-cell interactions   angiogenesis  

Academic Background The formation and maintenance of vascular networks are critical processes in embryonic development and tissue regeneration, involving the regulation of various biophysical forces. Endothelial cells (ECs) play a central role in angiogenesis and vasculogenesis, with the contractile forces of the cytoskeleton (actomyosin contractil...

Endothelial Metabolic Control of Insulin Sensitivity Through Resident Macrophages

Medicine, Rheumatology and Immunology, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Immunology,
endothelial cells   glucose metabolism   insulin resistance   resident macrophages   muscle insulin sensitivity  

Endothelial Cells Influence Insulin Sensitivity Through Metabolic Regulation of Resident Macrophages In recent years, metabolic diseases, especially insulin resistance and diabetes, have become significant global health issues. Muscle tissue, being one of the main organs for glucose metabolism in the human body, has its insulin sensitivity closely ...

Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis

Medicine, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Immunology,
dopaminylation   endothelial cells   TPI1   ferroptosis   lung regeneration   fibrosis   metabolism  

Dopamine Modification of TPI1 Inhibits Ferroptosis Signaling in Vascular Endothelial Cells, Promoting Lung Regeneration and Inhibiting Fibrosis Background The regenerative capability of the lung enables it to restore its original functional tissue after injury. However, if this regenerative process is disrupted, it often leads to maladaptive repair...