GDF15 Antagonism Limits Severe Heart Failure and Prevents Cardiac Cachexia

Heart Failure (HF) is a complex disease with increasing incidence and poor prognosis. Cardiac cachexia, a common complication in HF patients, is characterized by significant weight loss, muscle wasting, and malnutrition, and its occurrence is independently associated with patient morbidity and mortality. Although cardiac cachexia is prevalent in HF...

The Crosstalk Between Macrophages and Cancer Cells Potentiates Pancreatic Cancer Cachexia

Interactive Mechanisms Between Cancer Cells and Macrophages Facilitate Pancreatic Cancer Cachexia Background Pancreatic cancer is currently the third leading cause of cancer-related death in the United States and is expected to become the second leading cause of cancer death within the next decade. Unfortunately, more than 80% of pancreatic cancer ...