Cataract-Prone Variants of γD-Crystallin Populate a Conformation with a Partially Unfolded N-Terminal Domain under Native Conditions

Life Sciences, Biochemistry,
γD-crystallin   cataract   protein folding   hydrogen–deuterium exchange mass spectrometry   structural intermediate   aggregation   eye lens  

Study on Partially Unfolded Intermediate of γD-Crystallin Variants under Native Conditions Academic Background Human γD-crystallin is a structural protein in the eye lens, crucial for maintaining its transparency and stability. It must remain folded throughout an individual’s lifetime to avoid aggregation and protein deposition, thus preventing cat...

Neural Network Powered Microscopic System for Cataract Surgery

Neural Network Powered Microscopic System for Cataract Surgery

Information Science, Automation, Artificial Intelligence, Medicine, Ophthalmology, Medical Imaging,
cataract   surgical navigation   artificial intelligence   microscopic system   neural network   real-time positioning   eye rotation tracking  

Neural Network-Powered Microsurgical System: Advancing Precision in Cataract Surgery Academic Context and Research Problem Cataracts are the leading cause of blindness worldwide. Phacoemulsification combined with intraocular lens (IOL) implantation has emerged as the primary treatment method. This approach not only significantly improves patients’ ...

Cataracts Associated with Fibroblast Growth Factor Receptor Inhibitors for Cholangiocarcinoma

Medicine, Hepatobiliary System, Ophthalmology, Oncology,
cataract   cholangiocarcinoma   fibroblast growth factor receptor inhibitors   ophthalmic complications   retrospective study  

Academic Background and Problem Statement Fibroblast growth factor receptor inhibitors (FGFRi) are a class of targeted drugs used to treat intrahepatic cholangiocarcinoma (iCCA). Although FGFRi has shown significant efficacy in treating iCCA, the potential complications associated with their long-term use have not been fully studied. In particular,...