G-quadruplexes Catalyze Protein Folding by Reshaping the Energetic Landscape

Chemistry, Physical Chemistry, Medicine, Life Sciences, Biochemistry,
protein folding   G-quadruplex   energy landscape   molecular chaperone   nucleic acid  

G-Quadruplexes Catalyze Protein Folding: A Research Report Academic Background Protein folding is a complex and unsolved problem in biology. Many proteins fold very slowly in vitro, far exceeding the time ranges acceptable under physiological conditions. To address this challenge, ATP (adenosine triphosphate)-dependent chaperonins are thought to ac...

Cataract-Prone Variants of γD-Crystallin Populate a Conformation with a Partially Unfolded N-Terminal Domain under Native Conditions

Life Sciences, Biochemistry,
γD-crystallin   cataract   protein folding   hydrogen–deuterium exchange mass spectrometry   structural intermediate   aggregation   eye lens  

Study on Partially Unfolded Intermediate of γD-Crystallin Variants under Native Conditions Academic Background Human γD-crystallin is a structural protein in the eye lens, crucial for maintaining its transparency and stability. It must remain folded throughout an individual’s lifetime to avoid aggregation and protein deposition, thus preventing cat...

Spatial Covariance Reveals Isothiocyanate Natural Products Adjust Redox Stress to Restore Function in Alpha-1-Antitrypsin Deficiency

Medicine, Hepatobiliary System, Respiratory System, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
spatial covariance   isothiocyanate   redox stress   alpha-1-antitrypsin deficiency   natural products   protein folding   nutraceuticals  

Potential Therapeutic Role of Dietary Isothiocyanate Compounds in Alpha-1 Antitrypsin Deficiency (AATD) Background and Significance of the Study Alpha-1 Antitrypsin Deficiency (AATD) is a congenital, monogenic disease primarily caused by the misfolding of alpha-1 antitrypsin (AAT) in the liver. This misfolding leads to two pathological effects: the...

Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Biophysics,
protein folding   protein structure prediction   deep learning   transformer   language model  

Protein Structure Prediction: Challenges, Progress, and Shifts in Research Paradigms Protein structure prediction is an important interdisciplinary research topic that has attracted researchers from various fields including biochemistry, medicine, physics, mathematics, and computer science. Researchers have adopted multiple research paradigms to so...