Academic Background With the rapid advancement of sequencing technology, scientists have been able to obtain a vast amount of protein sequence data, including many enzyme sequences. However, despite the establishment of large enzyme databases such as the Kyoto Encyclopedia of Genes and Genomes (KEGG) and BRENDA, sequence information for many enzyme...

Linking microbial evolution and ecological restructuring in the human gut Background: The human gut harbors hundreds of microbial species that interact with each other in a complex ecological network. Recent studies have shown that gut microbes can evolve within human-relevant timescales, but little is known about how this evolution impacts (or is ...