HIF-1α and MIF Enhance Neutrophil-Driven Type 3 Immunity and Chondrogenesis in a Murine Spondyloarthritis Model

Medicine, Rheumatology and Immunology, Life Sciences, Biochemistry, Immunology,
hypoxia-inducible factor-1 alpha   macrophage migration inhibitory factor   neutrophil   spondyloarthritis   chondrogenesis   cytokine   STAT3  

Research Background and Research Questions Spondyloarthritis (SpA) is a typical disease characterized by type 3 immune-driven inflammation and new bone formation (NBF). Although previous studies have shown that Macrophage Migration Inhibitory Factor (MIF) plays a key role in the pathogenesis of SpA, its interactions with other molecules and specifi...