Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
neutrophil   citrullination   CKMT1   intestinal epithelial cells   inflammatory bowel disease   intestinal inflammation   apoptosis  

In recent years, increasing evidence from research on Inflammatory Bowel Disease (IBD) has shown that neutrophils play a crucial role in the occurrence and development of intestinal inflammation. IBD includes Crohn’s Disease (CD) and Ulcerative Colitis (UC), and while its pathogenesis is not yet fully understood, abnormal immune responses are clear...

HIF-1α and MIF Enhance Neutrophil-Driven Type 3 Immunity and Chondrogenesis in a Murine Spondyloarthritis Model

Medicine, Rheumatology and Immunology, Life Sciences, Biochemistry, Immunology,
hypoxia-inducible factor-1 alpha   macrophage migration inhibitory factor   neutrophil   spondyloarthritis   chondrogenesis   cytokine   STAT3  

Research Background and Research Questions Spondyloarthritis (SpA) is a typical disease characterized by type 3 immune-driven inflammation and new bone formation (NBF). Although previous studies have shown that Macrophage Migration Inhibitory Factor (MIF) plays a key role in the pathogenesis of SpA, its interactions with other molecules and specifi...