HIF-1α and MIF Enhance Neutrophil-Driven Type 3 Immunity and Chondrogenesis in a Murine Spondyloarthritis Model

Medicine, Rheumatology and Immunology, Life Sciences, Biochemistry, Immunology,
hypoxia-inducible factor-1 alpha   macrophage migration inhibitory factor   neutrophil   spondyloarthritis   chondrogenesis   cytokine   STAT3  

Research Background and Research Questions Spondyloarthritis (SpA) is a typical disease characterized by type 3 immune-driven inflammation and new bone formation (NBF). Although previous studies have shown that Macrophage Migration Inhibitory Factor (MIF) plays a key role in the pathogenesis of SpA, its interactions with other molecules and specifi...

Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance Through the IL-6/STAT3 Axis

Medicine, Oncology, Life Sciences, Immunology,
NK cells   MDSC   tumor immune escape   IL-6   STAT3   antigen presentation   immune checkpoint inhibition  

Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance via the IL-6/STAT3 Axis — Research by Neo et al. In recent years, researchers have delved deeply into the mechanisms of tumor immune escape to improve the success rate of cancer immunotherapy. The accumulation of CD8 T cells in the tumor microenvironment is a critical determinant ...