HIF-1α and MIF Enhance Neutrophil-Driven Type 3 Immunity and Chondrogenesis in a Murine Spondyloarthritis Model

Research Background and Research Questions Spondyloarthritis (SpA) is a typical disease characterized by type 3 immune-driven inflammation and new bone formation (NBF). Although previous studies have shown that Macrophage Migration Inhibitory Factor (MIF) plays a key role in the pathogenesis of SpA, its interactions with other molecules and specifi...

The Molecular Regulation of Astroglia-Driven Neuroinflammation in Experimental Glaucoma

Research Background Glaucoma is a major cause of blindness, characterized by complex neurodegenerative conditions that include extensive inflammatory responses in glial cells, accompanied by the progressive loss of Retinal Ganglion Cells (RGCs), optic nerve axons, and synaptic connections. Although there are variations in subtypes, topologies, and ...