The Endocannabinoid 2-Arachidonoylglycerol is Released and Transported on Demand via Extracellular Microvesicles

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Biophysics,
endocannabinoid   2-arachidonoylglycerol   extracellular microvesicles   on-demand release   neurotransmission   cannabinoid receptor   neuron  

Endocannabinoids Released on Demand via Extracellular Microvesicles Academic Background Endocannabinoids (ECBs) are a class of lipid neurotransmitters that play a critical role in brain function by activating cannabinoid receptor CB1. Unlike classical neurotransmitters, the storage and release mechanisms of ECBs have remained elusive, leading to si...

Oxyglutamate Carrier Alleviates Cerebral Ischaemia–Reperfusion Injury by Regulating Mitochondrial Function

Medicine, Neurology, Life Sciences,
cerebral ischaemia–reperfusion injury   mitochondrial function   neuron   oxyglutamate carrier   reactive oxygen species  

The Role of Oxyglutamate Carrier in Cerebral Ischemia-Reperfusion Injury Academic Background Cerebral ischemia-reperfusion injury (I/R) is a significant issue in the treatment of ischemic stroke. Although rapid blood flow restoration through thrombectomy and intravenous rt-PA (recombinant tissue plasminogen activator) administration can effectively...