Inhibition of YIPF2 Improves the Vulnerability of Oligodendrocytes to Human Islet Amyloid Polypeptide

Study on YIPF2 Inhibitors Improving Oligodendrocyte Susceptibility to Human Islet Amyloid Polypeptide With the dramatic increase in global diabetes prevalence, the harm of diabetes complications is becoming increasingly prominent. Among them, Diabetic Encephalopathy (DE), as the most common complication in type 2 diabetes, severely affects patients...

Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS

Background Introduction In this paper, the researchers discuss the impact of aging on the functionality of all cell types in the central nervous system (CNS) and its role in neurological diseases such as multiple sclerosis (MS). However, the molecular mechanisms underlying these age-related changes and their contribution to diseases remain poorly u...

Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis

Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis

This paper reports an original study on the dynamics of oligodendrocytes in the mouse cortex and white matter using three-photon microscopy. Introduction: Oligodendrocytes are the cells that produce myelin in the central nervous system, which is crucial for neural transmission, cognitive function, and injury repair. Previous studies have shown regi...