Clinicogenomic Landscape of Pancreatic Adenocarcinoma Identifies KRAS Mutant Dosage as Prognostic of Overall Survival

Medicine, Hepatobiliary System, Gastroenterology, Oncology,
pancreatic cancer   KRAS mutation   genomic landscape   prognostic marker   clinical study  

Clinicogenomic Landscape of Pancreatic Ductal Adenocarcinoma: The Prognostic Role of KRAS Mutation Dosage Academic Background Pancreatic ductal adenocarcinoma (PDAC), the most common histological type of pancreatic cancer, is the third leading cause of cancer-related mortality and has the lowest five-year survival rate among all cancer types. Over ...

Delactylase Effects of Sirt1 on a Positive Feedback Loop Involving the H19-Glycolysis-Histone Lactylation in Gastric Cancer

Medicine, Gastroenterology, Oncology, Life Sciences, Biochemistry,
gastric cancer   histone lactylation   Sirt1   glycolysis   H19   therapeutic strategy   prognostic marker  

Academic Background and Problem Statement Gastric Cancer (GC) is one of the most common cancers worldwide, with approximately 1.1 million new cases diagnosed in 2020. Although advancements in early detection, surgical techniques, and oncology have led to a decline in GC mortality, the treatment of advanced or metastatic GC remains a significant cha...