Delactylase Effects of Sirt1 on a Positive Feedback Loop Involving the H19-Glycolysis-Histone Lactylation in Gastric Cancer

Academic Background and Problem Statement Gastric Cancer (GC) is one of the most common cancers worldwide, with approximately 1.1 million new cases diagnosed in 2020. Although advancements in early detection, surgical techniques, and oncology have led to a decline in GC mortality, the treatment of advanced or metastatic GC remains a significant cha...