EVA1-Antibody Drug Conjugate as a Novel Therapeutic Strategy for Eliminating Glioblastoma-Initiating Cells

Medicine, Neurology, Oncology, Life Sciences, Immunology,
glioblastoma   EVA1   antibody drug conjugate   tumor-initiating cells   therapeutic strategy  

Background Introduction Glioblastoma (GBM) is one of the most aggressive brain cancers, with a median survival of approximately 15 months. Despite the use of multimodal treatments including surgery, chemotherapy, and radiotherapy, the overall survival rate of GBM patients has not significantly improved over the past few decades. Recent studies have...

The Alcatraz-Strategy: A Roadmap to Break the Connectivity Barrier in Malignant Brain Tumours

Medicine, Neurology, Neurosurgery, Oncology,
malignant brain tumours   cellular networks   supramarginal resection   tumour microtubes   cell-to-cell connections   therapeutic strategy   gliomas  

Cellular Network Connectivity and Therapeutic Strategies in Malignant Brain Tumors Academic Background Malignant brain tumors, particularly glioblastoma, are among the most aggressive and lethal tumors in the central nervous system. Despite significant advancements in tumor biology and treatment methods in recent years, the median survival for glio...

MYC-Dependent Upregulation of the De Novo Serine and Glycine Synthesis Pathway is a Targetable Metabolic Vulnerability in Group 3 Medulloblastoma

Medicine, Neurology, Neurosurgery, Oncology,
medulloblastoma   MYC amplification   metabolic vulnerability   serine synthesis   glycine synthesis   PHGDH inhibition   therapeutic strategy  

Targeting the Serine/Glycine Synthesis Pathway in MYC-Driven Medulloblastoma Background Medulloblastoma is one of the most common malignant brain tumors in children, accounting for a significant proportion of childhood cancer deaths. Based on molecular characteristics, medulloblastoma is classified into four major subgroups: WNT, SHH, Group 3 (MBGr...

Delactylase Effects of Sirt1 on a Positive Feedback Loop Involving the H19-Glycolysis-Histone Lactylation in Gastric Cancer

Medicine, Gastroenterology, Oncology, Life Sciences, Biochemistry,
gastric cancer   histone lactylation   Sirt1   glycolysis   H19   therapeutic strategy   prognostic marker  

Academic Background and Problem Statement Gastric Cancer (GC) is one of the most common cancers worldwide, with approximately 1.1 million new cases diagnosed in 2020. Although advancements in early detection, surgical techniques, and oncology have led to a decline in GC mortality, the treatment of advanced or metastatic GC remains a significant cha...