Delactylase Effects of Sirt1 on a Positive Feedback Loop Involving the H19-Glycolysis-Histone Lactylation in Gastric Cancer

Academic Background and Problem Statement Gastric Cancer (GC) is one of the most common cancers worldwide, with approximately 1.1 million new cases diagnosed in 2020. Although advancements in early detection, surgical techniques, and oncology have led to a decline in GC mortality, the treatment of advanced or metastatic GC remains a significant cha...

LGALS9B stabilizes EEF1D protein and activates the PI3K/AKT signaling pathway to promote gastric cancer occurrence and metastasis

lgals9b Stabilizes eef1d Protein and Activates the PI3K/AKT Signaling Pathway to Promote Gastric Cancer Occurrence and Metastasis Academic Background Gastric cancer ranks as the fifth most prevalent cancer globally, with over one million new cases diagnosed annually. Due to late detection, it exhibits a high mortality rate and is the fourth leading...

Retrospective Study of Claudin 18 Isoform 2 Prevalence and Prognostic Association in Gastric and Gastroesophageal Junction Adenocarcinoma

Research Report on Claudin 18.2 in Gastric Cancer and Gastroesophageal Junction Adenocarcinoma Background Introduction Gastric cancer and gastroesophageal junction (G/GEJ) adenocarcinoma are major global health burdens. It is estimated that in 2020 alone, there were approximately 1.7 million new cases of gastric and esophageal cancers worldwide, wi...

Autoimmune Conditions and Gastric Cancer Risk in a Population-Based Study in the United Kingdom

The Relationship Between Autoimmune Diseases and Gastric Cancer Risk in the British Population Background Introduction Despite the overall incidence of gastric cancer has declined over the past few decades, the incidence of gastric cancer among young people in some Western countries has increased in recent years. This trend may be related to the in...

Enhanced Epithelial-Mesenchymal Transition Signatures Are Linked with Adverse Tumor Microenvironment, Angiogenesis, and Worse Survival in Gastric Cancer

Enhanced EMT Characteristics Associated with Unfavorable Tumor Microenvironment, Angiogenesis, and Poorer Prognosis in Gastric Cancer Academic Background Epithelial-Mesenchymal Transition (EMT) is an extremely important mechanism that promotes the metastasis of cancer cells. However, despite its apparent importance, the clinical significance of EMT...