Complete Substitution with Modified Nucleotides in Self-Amplifying RNA Suppresses the Interferon Response and Increases Potency

Life Sciences, Cell Biology, Bioengineering, Genetics,
modified nucleotides   self-amplifying RNA   interferon response   protein expression   vaccine   SARS-CoV-2  

Introduction Under the influence of the COVID-19 pandemic, mRNA vaccine technology has made significant advances. However, its short half-life and high dosage requirements have led to side effects and accessibility issues. To overcome these challenges, self-amplifying RNA (saRNA) has become a research hotspot. saRNA utilizes RNA-dependent RNA polym...

A 5' UTR Language Model for Decoding Untranslated Regions of mRNA and Function Predictions

A 5' UTR Language Model for Decoding Untranslated Regions of mRNA and Function Predictions

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
language model   5' UTR   mRNA translation   protein expression   function prediction  

The 5’ untranslated region (5’UTR) is a regulatory region at the start of messenger RNA (mRNA) molecules, playing a crucial role in regulating the translation process and affecting protein expression levels. Language models have demonstrated effectiveness in decoding protein and genomic sequence functions. In this study, the authors introduce a lan...