Complete Substitution with Modified Nucleotides in Self-Amplifying RNA Suppresses the Interferon Response and Increases Potency

Life Sciences, Cell Biology, Bioengineering, Genetics,
modified nucleotides   self-amplifying RNA   interferon response   protein expression   vaccine   SARS-CoV-2  

Introduction Under the influence of the COVID-19 pandemic, mRNA vaccine technology has made significant advances. However, its short half-life and high dosage requirements have led to side effects and accessibility issues. To overcome these challenges, self-amplifying RNA (saRNA) has become a research hotspot. saRNA utilizes RNA-dependent RNA polym...

Dendritic-Cell-Targeting Virus-Like Particles as Potent mRNA Vaccine Carriers

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
dendritic cells   virus-like particles   mRNA vaccine   SARS-CoV-2   high efficacy  

Dendritic-cell-targeting Virus-like Particles as Potent mRNA Vaccine Carriers Introduction In vaccine development, especially mRNA vaccines, significant achievements have been made in recent years. The mRNA vaccines developed by Moderna and Pfizer/BioNTech against COVID-19 have set a successful precedent, greatly advancing the development of mRNA v...