Functional and Epigenetic Changes in Monocytes from Adults Immunized with an AS01-Adjuvanted Vaccine

Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
vaccine   monocytes   AS01 adjuvant   epigenetics   immune response   activation  

Long-term Functional and Epigenetic Changes in Adult Monocytes Induced by AS01-adjuvanted Vaccine Background: Vaccine adjuvants are widely used to enhance the immune response of vaccines. In particular, the AS01 adjuvant, a key component in several approved vaccines, has demonstrated high immunogenicity and efficacy. AS01 exerts its adjuvant effect...

Complete Substitution with Modified Nucleotides in Self-Amplifying RNA Suppresses the Interferon Response and Increases Potency

Life Sciences, Cell Biology, Bioengineering, Genetics,
modified nucleotides   self-amplifying RNA   interferon response   protein expression   vaccine   SARS-CoV-2  

Introduction Under the influence of the COVID-19 pandemic, mRNA vaccine technology has made significant advances. However, its short half-life and high dosage requirements have led to side effects and accessibility issues. To overcome these challenges, self-amplifying RNA (saRNA) has become a research hotspot. saRNA utilizes RNA-dependent RNA polym...