Repurposing Diacerein for the Treatment of Chronic Wounds in Recessive-Dystrophic Epidermolysis Bullosa Patients by Modulating Matrix Metalloproteinase-9 Expression

Medicine, Infectious Diseases, Life Sciences, Immunology,
diacerein   matrix metalloproteinase-9   recessive-dystrophic epidermolysis bullosa   chronic wounds   skin inflammation  

Research Background Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic skin disorder caused by mutations in the COL7A1 gene, leading to the absence or dysfunction of type VII collagen (C7). Type VII collagen is a crucial protein for maintaining skin structural stability, and its deficiency makes patients’ skin extremely fragile, pr...

Skin-Permeable Gold Nanoparticles with Azelamide Monoethanolamine Modifications Ameliorate Inflammatory Skin Diseases

Chemistry, Nanoscience, Medicinal Chemistry, Materials Science, Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
gold nanoparticles   azelamide monoethanolamine   skin inflammation   topical therapeutics   oxidative stress   matrix metalloproteinase   superoxide dismutase  

Report on the Academic Paper Inflammatory skin diseases, such as psoriasis and rosacea, are common chronic skin conditions worldwide, significantly impacting patients’ quality of life. Traditional topical drug delivery methods, while simple and non-invasive, suffer from poor skin penetration and long-term side effects. Therefore, developing an effe...