Maternal Folic Acid Over-Supplementation Impairs Cardiac Function in Mice Offspring by Inhibiting SOD1 Expression

Medicine, Obstetrics and Gynecology, Cardiovascular System, Life Sciences,
folic acid   over-supplementation   cardiac function   superoxide dismutase 1   N-acetylcysteine  

Background Folic Acid (FA) supplementation during pregnancy is widely recommended to reduce the risk of fetal congenital defects, particularly in the prevention of neural tube defects and congenital heart disease. However, despite the significant benefits of FA supplementation in preventing certain diseases, whether excessive FA supplementation may...

Seeding Activity of Human Superoxide Dismutase 1 Aggregates in Familial and Sporadic Amyotrophic Lateral Sclerosis Postmortem Neural Tissues by Real-Time Quaking-Induced Conversion

Medicine, Basic Medical Sciences, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry,
superoxide dismutase 1   amyotrophic lateral sclerosis   protein aggregation   sporadic ALS   familial ALS   real-time quaking-induced conversion  

Detection of Seeding Activity of Human Superoxide Dismutase 1 Aggregates in Postmortem Neural Tissues of Familial and Sporadic Amyotrophic Lateral Sclerosis Patients Background Introduction Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressing neurodegenerative disease with an average survival time of 2 to 5 years after diagnosis. Major symp...