Academic Background Pregnant women undergo significant physiological changes in their cardiovascular system to meet the increased physiological demands during pregnancy. Among these changes, an increase in resting heart rate (HR) is common, typically rising by 10-20 beats per minute. However, this increase in HR can lead to the onset or exacerbatio...
Background Folic Acid (FA) supplementation during pregnancy is widely recommended to reduce the risk of fetal congenital defects, particularly in the prevention of neural tube defects and congenital heart disease. However, despite the significant benefits of FA supplementation in preventing certain diseases, whether excessive FA supplementation may...
Multi-omics technology reveals the mechanism of endometrial decidualization resistance in patients with severe preeclampsia Academic background Preeclampsia (PE) is a common and serious complication during pregnancy, primarily characterized by hypertension, proteinuria, and dysfunction of other organs, posing a significant threat to maternal and fe...
Research Report on Low-Energy Diet Intervention in Gestational Diabetes Academic Background Gestational Diabetes Mellitus (GDM) is a form of diabetes diagnosed for the first time during pregnancy, with a global incidence rate of approximately 6-15%. GDM not only increases the risk of short-term complications for both mothers and fetuses, such as la...
Application of Automation Technology in Embryo Trophectoderm Cell Biopsy Academic Background Embryo biopsy is a crucial step in assisted reproductive technology (In Vitro Fertilization, IVF), especially in Preimplantation Genetic Testing (PGT). Through embryo biopsy, doctors can extract a small number of cells from embryos for genetic analysis to a...
Mechanism Study of p300 Maintaining Primordial Follicle Activation by Inhibiting VEGFA Transcription Academic Background In the female reproductive system, primordial follicles (PFs) are the earliest formed follicles in the ovary, remaining dormant and awaiting activation to enter the growth phase. The activation of primordial follicles is a key fa...
Histone Lactylation Promotes Endometriosis Progression by Upregulating CTPS1 SUMOylation Academic Background Endometriosis is a common reproductive endocrine disease affecting approximately 10% of women of reproductive age worldwide. Its main symptoms include dysmenorrhea, chronic pelvic pain, infertility, and menstrual abnormalities. Although the ...
Research Background and Problem Introduction Protein O-GlcNAc glycosylation is an important post-translational modification that plays a critical role in cellular metabolic plasticity. Aberrant O-GlcNAc glycosylation levels have been observed in various cancers, including endometrial cancer (EC), a common malignancy in women. However, clinical char...
Melatonin Alleviates High Temperature Exposure-Induced Fetal Growth Restriction via the Gut-Placenta-Fetus Axis Research Background Global climate warming has become a significant threat to human health, particularly affecting pregnant women and fetuses. Studies have shown that high-temperature exposure increases the risk of adverse pregnancy outco...
Exploring the Impacts of Senescence on Implantation and Early Embryonic Development Using Totipotent Cell-Derived Blastoids Academic Background With the increasing trend of delayed childbearing in modern society, reproductive issues among women of advanced maternal age (AMA) have become increasingly prominent. Studies have shown that the implantati...