Single-cell RNA Sequencing of Peripheral Blood Links Cell-Type-Specific Regulation of Splicing to Autoimmune and Inflammatory Diseases

Medicine, Rheumatology and Immunology, Life Sciences, Immunology, Genetics,
Single-cell RNA sequencing   Splicing regulation   Autoimmune diseases   Inflammatory diseases   Cell-type specificity   Genetic diversity   Asian Immune Diversity Atlas  

Single-cell RNA Sequencing Reveals Cell-type-specific Splicing Regulation in Peripheral Blood Linked to Autoimmune and Inflammatory Diseases Background In recent years, rapid advancements in genomics research have provided deeper insights into the genetic basis of complex traits. However, the functional mechanisms underlying most disease-associated...

Differences in the Characteristics and Functions of Brain and Spinal Cord Regulatory T Cells

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Immunology,
Regulatory T cells   Autoimmune diseases   Brain   Spinal cord   Tissue-specificity   Inflammation suppression   Immune tolerance  

Research Report: Differential Characteristics and Functions of Regulatory T Cells in the Brain and Spinal Cord Research Background and Motivation This study explored the characteristics and functional differences of regulatory T cells (Tregs) within the central nervous system (CNS). Tregs play a key role in the adaptive immune response, primarily b...