Contrastive Mapping Learning for Spatial Reconstruction of Single-Cell RNA Sequencing Data

Information Science, Computer Science, Artificial Intelligence, Medicine, Life Sciences, Bioengineering,
Single-cell RNA sequencing   Spatial transcriptomics   Contrastive learning   Cell correspondence   Gene expression  

Single-cell RNA sequencing (scRNA-seq) technology enables high-throughput transcriptomic profiling at single-cell resolution, significantly advancing research in cell biology. However, a notable limitation of scRNA-seq is that it requires tissue dissociation, resulting in the loss of the original spatial location information of cells within tissues...

ACImpute: A Constraint-Enhancing Smooth-Based Approach for Imputing Single-Cell RNA Sequencing Data

Information Science, Computer Science, Life Sciences, Bioengineering,
Single-cell RNA sequencing   Data imputation   Constraint-enhancing smooth   Cluster analysis   Trajectory inference  

Single-cell RNA sequencing (scRNA-seq) technology has been widely applied in biological and medical research in recent years. It can reveal the transcriptomic information of individual cells, helping scientists better understand cellular heterogeneity and complexity. However, a common issue in scRNA-seq data is “dropout events,” which result in man...

Organ-Specific Microenvironments Drive Divergent T Cell Evolution in Acute Graft-Versus-Host Disease

Medicine, Rheumatology and Immunology, Hepatobiliary System, Respiratory System, Gastroenterology, Hematology, Life Sciences, Immunology,
Graft-versus-host disease   T cell evolution   Organ microenvironment   Immunopathology   Single-cell RNA sequencing  

Study on Organ-Specific T Cell Differentiation in Acute Graft-Versus-Host Disease (AGVHD) Academic Background Acute Graft-Versus-Host Disease (AGVHD) is a common and severe complication following Allogeneic Hematopoietic Stem Cell Transplantation (HCT), caused by the immune attack of donor T cells on host tissues. Although the pathological mechanis...

Single-cell RNA Sequencing of Peripheral Blood Links Cell-Type-Specific Regulation of Splicing to Autoimmune and Inflammatory Diseases

Medicine, Rheumatology and Immunology, Life Sciences, Immunology, Genetics,
Single-cell RNA sequencing   Splicing regulation   Autoimmune diseases   Inflammatory diseases   Cell-type specificity   Genetic diversity   Asian Immune Diversity Atlas  

Single-cell RNA Sequencing Reveals Cell-type-specific Splicing Regulation in Peripheral Blood Linked to Autoimmune and Inflammatory Diseases Background In recent years, rapid advancements in genomics research have provided deeper insights into the genetic basis of complex traits. However, the functional mechanisms underlying most disease-associated...

Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA-seq and Bulk RNA-seq: A Model Development and Validation Study

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
Esophageal squamous cell carcinoma   Glucose metabolism   Immune infiltration   Prognosis   Single-cell RNA sequencing   Bulk RNA sequencing   Bioinformatics  

Prognostic Prediction Model for Esophageal Squamous Cell Carcinoma Based on Single-Cell RNA Sequencing and Bulk RNA Sequencing Research Background Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors globally, particularly prevalent in East Asia. Despite existing treatment methods such as surgery, endoscopic resectio...

Single-Cell Analysis Reveals Alterations Between the Aged and Young Mice Prostates

Medicine, Urology, Life Sciences, Cell Biology, Immunology,
Single-cell RNA sequencing   Prostate aging   Cellular heterogeneity   Gene expression   Mouse model  

Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...