4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20

Medicine, Rheumatology and Immunology, Hematology, Life Sciences, Immunology,
chimeric antigen receptor   CAR-T cell   4-1BB   apoptosis   necroptosis   A20   NF-κB  

Background Introduction Chimeric antigen receptor T cells (CAR-T cells) have shown great potential in immunotherapy for certain hematological malignancies. However, how the CD28 and 4-1BB costimulatory domains included in CAR molecules function in CAR-T cells is still not fully understood. Both CD28 and 4-1BB domains exhibit significantly different...