4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20

Medicine, Rheumatology and Immunology, Hematology, Life Sciences, Immunology,
chimeric antigen receptor   CAR-T cell   4-1BB   apoptosis   necroptosis   A20   NF-κB  

Background Introduction Chimeric antigen receptor T cells (CAR-T cells) have shown great potential in immunotherapy for certain hematological malignancies. However, how the CD28 and 4-1BB costimulatory domains included in CAR molecules function in CAR-T cells is still not fully understood. Both CD28 and 4-1BB domains exhibit significantly different...

Therapeutic Intervention in Neuroinflammation for Neovascular Ocular Diseases through Targeting the cGAS-STING pathway

Therapeutic Intervention in Neuroinflammation for Neovascular Ocular Diseases through Targeting the cGAS-STING pathway

Medicine, Neurology, Ophthalmology, Life Sciences, Immunology,
pathological angiogenesis   STING   myeloid cells   necroptosis   neuroinflammation   immunotherapy   neovascular ocular diseases  

The Key Role of Retina Microglia in Pathological Angiogenesis and the Immunotherapeutic Potential of the cGAS-STING Pathway Background Pathological angiogenesis is common in various neovascular ophthalmic diseases, such as Diabetic Retinopathy (DR) and Age-related Macular Degeneration (AMD) [1]. During these diseases, bone marrow cells, including r...