Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes under Ischemic Conditions

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
inflammasome   fibrous astrocytes   protoplasmic astrocytes   ischemic stroke   apoptosis   pyroptosis   cell death  

Inflammasome Activation Regulates Apoptosis and Pyroptosis in Astrocytes under Ischemic Conditions Introduction Ischemic stroke is one of the main mechanisms leading to brain damage, characterized by hypoxia and energy deprivation in local brain regions due to interrupted blood flow. In recent years, research has found that inflammatory responses p...

A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
AIFM1   mitochondria   riboflavin   apoptosis   ataxia   neuropathy  

Missense Mutation in AIFM1 Gene Leads to Mitochondrial Dysfunction and Riboflavin Deficiency Intolerance Research Background Mitochondria are double-membrane organelles found in eukaryotic cells with nuclei, primarily producing adenosine triphosphate (ATP) through oxidative phosphorylation to provide cellular energy. Mitochondria have their own gen...

MERTK Reduces Blood-Spinal Cord Barrier Permeability Through the RhoA/ROCK1/P-MLC Pathway After Spinal Cord Injury

Medicine, Neurosurgery,
spinal cord injury   MERTK   blood-spinal cord barrier   RhoA/ROCK1/P-MLC pathway   apoptosis   inflammation  

Study on MERTK Reducing Blood-Spinal Cord Barrier Permeability after Spinal Cord Injury via RhoA/ROCK1/p-MLC Pathway Spinal Cord Injury (SCI) is a central nervous system disease caused by trauma, inflammation, tumors, or other pathological reasons, resulting in sensory, motor, and autonomic nervous system dysfunction in patients, imposing a heavy b...

4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20

Medicine, Rheumatology and Immunology, Hematology, Life Sciences, Immunology,
chimeric antigen receptor   CAR-T cell   4-1BB   apoptosis   necroptosis   A20   NF-κB  

Background Introduction Chimeric antigen receptor T cells (CAR-T cells) have shown great potential in immunotherapy for certain hematological malignancies. However, how the CD28 and 4-1BB costimulatory domains included in CAR molecules function in CAR-T cells is still not fully understood. Both CD28 and 4-1BB domains exhibit significantly different...

Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
neutrophil   citrullination   CKMT1   intestinal epithelial cells   inflammatory bowel disease   intestinal inflammation   apoptosis  

In recent years, increasing evidence from research on Inflammatory Bowel Disease (IBD) has shown that neutrophils play a crucial role in the occurrence and development of intestinal inflammation. IBD includes Crohn’s Disease (CD) and Ulcerative Colitis (UC), and while its pathogenesis is not yet fully understood, abnormal immune responses are clear...

Putting the STING Back into BH3-Mimetic Drugs for TP53-Mutant Blood Cancers

Medicine, Hematology, Oncology, Life Sciences, Biochemistry, Genetics,
TP53 mutation   blood cancer   BH3-mimetic drugs   STING agonists   apoptosis   anti-cancer therapy  

Applying STING Function to BH3-Mimetic Drugs for Treating TP53 Mutant Blood Cancers In the recently published article in Cancer Cell titled “Putting the sting back into BH3-mimetic drugs for TP53-mutant blood cancers,” Sarah T. Diepstraten and colleagues conducted in-depth research to explore how to enhance the efficacy of BH3-mimetic drugs in TP53...