Flash Radiation Reprograms Lipid Metabolism and Macrophage Immunity and Sensitizes Medulloblastoma to CAR-T Cell Therapy

Medicine, Pediatrics, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
Flash radiation   Lipid metabolism   Macrophage   Medulloblastoma   CAR-T cell therapy   Immunosuppression   Tumor microenvironment  

Background Brain tumors, particularly medulloblastoma (MB) in children, are one of the leading causes of cancer-related deaths in pediatric populations. Despite advancements in treatments such as surgical resection, radiotherapy, and chemotherapy, the prognosis for high-risk MB remains poor. In recent years, immunotherapy, especially CAR-T cell the...

Ide-cel vs Standard Regimens in Triple-Class–Exposed Relapsed and Refractory Multiple Myeloma: Updated KARMMA-3 Analyses

Medicine, Hematology, Oncology, Life Sciences, Immunology,
multiple myeloma   relapsed and refractory   ide-cel   KARMMA-3 trial   CAR-T cell therapy   progression-free survival   overall survival  

Latest Research Report: Idecabtagene Vicleucel (ide-cel) Significantly Extends Progression-Free Survival in Triple-Class Exposed (TCE) Relapsed or Refractory Multiple Myeloma – Results from the KARMMA-3 Clinical Trial Academic Background and Research Question Patients with Multiple Myeloma (MM) often relapse after multiple lines of therapy, with pr...