The Critical Role of Wnt/β-catenin Signaling in Choroid Plexus Tumorigenesis Background Introduction The choroid plexus (CHP) is a secretory epithelial structure located in the brain ventricles, primarily responsible for the secretion of cerebrospinal fluid (CSF) and the establishment of the blood-CSF barrier. Choroid plexus tumors (CPTs) are rare ...
Advances in Risk Stratification and Treatment Strategies for Medulloblastoma Background Medulloblastoma is a common malignant brain tumor in children, with significant differences in treatment and prognosis depending on its molecular subtypes. In recent years, advances in molecular biology have revealed that medulloblastoma can be further divided i...
Distribution and Outcomes of Paediatric Anaesthesia Services in Sweden: An Epidemiological Study Academic Background In recent years, there has been a growing trend towards the centralization of perioperative care for children globally, particularly in European countries. This trend is primarily driven by research findings from professional organiz...
External Validation of Preoperative Risk Scores for 30-Day In-Hospital Mortality in Pediatric Patients Academic Background Although the perioperative mortality rate in pediatric patients is low (<0.5%), it remains a significant issue in clinical practice. Traditional risk assessment tools, such as the American Society of Anesthesiologists (ASA) Phy...
Academic Paper Report Caries is one of the most common chronic diseases in children, with significant health disparities across racial, ethnic, and income groups. Despite the availability of effective preventive measures, children from low-income and minority ethnic groups continue to face higher risks of caries. The American Academy of Pediatrics ...
Research Report on Pre-HCT Emapalumab Therapy Improving Donor Chimerism in Children with HLH Background and Objective of the Study Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune disorder caused by pathological immune activation. The primary mechanism involves the functional deficiency of cytotoxic activity in natural killer (...
Research on Juvenile Xanthogranuloma Reveals Novel Genetic Mutations Juvenile xanthogranuloma (JXG), a rare histiocytic neoplasm, typically manifests in the skin but occasionally presents extracutaneously in locations such as soft tissue or the central nervous system (CNS). The genetic drivers underlying these extracutaneous variants remain poorly ...
Review of the Study on Antimetabolite Dose Intensity and Adverse Outcomes in Children with Acute Lymphoblastic Leukemia (ALL) Background and Research Question Acute Lymphoblastic Leukemia (ALL) is the most common form of leukemia in children. Current treatment strategies include risk-based induction therapy, response-adapted post-induction therapy,...
Revisited Diagnostic Guidelines for Familial Hemophagocytic Lymphohistiocytosis (FHL) Based on HLH-2004: Updates to Diagnostic Criteria and Development of Multipathway Diagnostic Strategies Introduction Familial hemophagocytic lymphohistiocytosis (FHL) is a severe hyperinflammatory disease characterized by abnormal accumulation of macrophages and l...
Daratumumab in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma: The DELPHINUS Study Academic Background Acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL) are among the most common malignancies in children. Although the cure rate for newly diagnosed ALL and LL patients is relatively high, 10% to ...