Background Brain tumors, particularly medulloblastoma (MB) in children, are one of the leading causes of cancer-related deaths in pediatric populations. Despite advancements in treatments such as surgical resection, radiotherapy, and chemotherapy, the prognosis for high-risk MB remains poor. In recent years, immunotherapy, especially CAR-T cell the...
Infantile Hemangioma (IH) is the most common benign vascular tumor in children, with an incidence rate of approximately 4%-10%. Although most IH cases resolve spontaneously, some cases may lead to permanent pigmentation, fibrous tissue accumulation, and scarring, affecting the appearance and quality of life of children. Additionally, certain IH cas...
The Key Role of Human Milk Microbes and Oligosaccharides in Infant Gut Microbiota Development Academic Background The development of infant gut microbiota is crucial in early life, and breastfeeding is one of the key drivers of this process. Human milk not only provides essential nutrients for infants but also contains a rich array of microbes and ...
Academic Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Although recent advances in molecular characterization and multimodal treatment have significantly improved patient survival rates, the prognosis of medulloblastoma remains closely related to molecular subtypes, particularly for patients with Grou...
The Impact of Circadian Rhythms and Behavioral Cycles on Caloric Intake in Adolescents Varies by Weight Status Academic Background The prevalence of obesity continues to rise globally, particularly among adolescents, increasing the risk of various chronic diseases such as type 2 diabetes, hypertension, and cardiovascular disorders. While previous s...
Machine Learning Study on the Relationship Between Heart Rate and Body Temperature in Pediatric Intensive Care Units Academic Background In the pediatric intensive care unit (PICU), heart rate (HR) and body temperature (BT) are crucial clinical indicators that reflect a patient’s physiological status. Although the relationship between HR and BT has...
Study on Congenital Immune Dysfunction in Cystic Fibrosis Research Background Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, primarily affecting the lungs and digestive system. One of the major problems faced by CF patients is recurrent infections and inflammatio...
Biomarkers Associated with the Progression of Infantile Hemangioma: An Exploratory Study Academic Background Infantile Hemangioma (IH) is one of the most common benign tumors in infancy. Although most IH is not apparent at birth, it gradually manifests within the first month of life and undergoes a proliferative phase over approximately one year, f...
Tumor Metabolic Reprogramming Identifies Key Vulnerability in Pediatric Malignant Tumors – Comprehensive Research Based on Organoid Models Background Malignant Rhabdoid Tumors (MRT) are highly invasive pediatric cancers that primarily affect infants and can develop throughout the body, with the intracranial variant known as Atypical Teratoid/Rhabdo...
Comparison of Ozaki Technique and Ross Procedure in Children with Complex Aortic Valve Diseases Academic Background Aortic valve disease (AVD) in children is a complex and challenging condition, especially when surgical intervention is required. Traditional aortic valve replacement surgeries, such as mechanical or bioprosthetic valve replacements, ...