In Vivo Brain Delivery of BBB-Enabled Iduronate 2-Sulfatase in Rats

Medicine, Neurology, Life Sciences, Biochemistry,
blood brain barrier   MPS II   iduronate-2-sulfatase   enzyme replacement therapy   CSF   brain   pharmacokinetics  

Delivery of Enzyme Replacement Therapy Across the Blood-Brain Barrier for Hunter Syndrome Background Hunter syndrome (Mucopolysaccharidosis II, MPS II) is a rare inherited metabolic disorder caused by a deficiency of the iduronate-2-sulfatase (IDS) enzyme. This enzyme deficiency leads to the accumulation of glycosaminoglycans (such as heparan sulfa...

Phase-Contrast MRI Analysis of Cerebral Blood and CSF Flow Dynamic Interactions

Medicine, Neurology, Neurosurgery, Medical Imaging,
cerebral blood   CSF   volume change   intracranial   extracranial   flow dynamics   phase-contrast MRI  

Study on the Interaction Between Cerebral Blood Flow and Cerebrospinal Fluid Dynamics Measured at Intracranial and Extracranial Planes Background The interaction between cerebral blood flow (CBF) and cerebrospinal fluid (CSF) is a critical factor in maintaining intracranial pressure (ICP) stability. According to the Monro-Kellie doctrine, the intra...

Disease Staging of Alzheimer's Disease Using a CSF-Based Biomarker Model

Medicine, Basic Medical Sciences, Medical Laboratory Science, Neurology, Life Sciences, Biochemistry,
Alzheimer's disease   CSF   biomarkers   disease staging   diagnosis   prognosis  

Research Background and Objectives With over 50 million people worldwide affected by cognitive impairment disorders, this number is expected to double by 2050. Alzheimer’s disease (AD) is the most common form of dementia, characterized by extracellular amyloid-beta (Aβ) plaques and intracellular tau protein aggregates in the brain. Over the past tw...