Research Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the deposition of amyloid-beta (Aβ) plaques and abnormal phosphorylation of tau protein. Recent studies have increasingly highlighted the role of cerebrovascular alterations in the pathogenesis of AD. Specifically, endothelial cell damage and inflam...
Association of Plasma GFAP and p-tau-181 with Synaptic Density in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a multifactorial neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and tau protein aggregates in the brain. Recent research has shown that multiple factors are involved in the dev...
Gastrointestinal-Induced Spread of α-Synuclein and Tau Proteins Triggers Comorbid Pathology and Behavioral Impairments in Parkinson’s and Alzheimer’s Diseases Background Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) are two common neurodegenerative disorders, caused by the aggregation of α-synuclein (a-syn) and Tau protein in the brain, res...
A2A Adenosine Receptor Exacerbates Synaptic Loss and Memory Deficits in APP/PS1 Mice Alzheimer’s disease (AD) is a neurodegenerative disorder associated with progressive cognitive decline, characterized by the deposition of extracellular β-amyloid (Aβ) plaques and the accumulation of hyperphosphorylated tau protein in neurons. Some epidemiological ...
Study on the Circadian Rhythm of Orexin System Genes and Their Impact on Early Alzheimer’s Disease (AD) Pathology Research Background and Objectives Alzheimer’s Disease (AD) is a chronic degenerative disease of the central nervous system, characterized by senile plaques formed by β-amyloid protein (Aβ) aggregation and neurofibrillary tangles formed...
A Study Exploring a New Mutation in Early-Onset Alzheimer’s Disease Alzheimer’s Disease (AD) is a common neurodegenerative disorder, accounting for 60-70% of all dementia cases. In recent years, with global population aging and environmental changes, the incidence of AD has been increasing annually. It is predicted that by 2050, the number of patie...
Blue Autofluorescence Generated by Aβ Aggregation Illuminates Senile Plaques and Complex Blood and Vascular Pathologies in Alzheimer’s Disease Research Background Alzheimer’s disease (AD) is a widespread neurodegenerative disorder globally, with senile plaques being the main pathological hallmark of AD, primarily composed of β-amyloid protein (Aβ)....
Low-dose IL-2 treatment rescues cognitive deficits by repairing the imbalance between Treg and Th17 cells at the middle Alzheimer’s disease stage Background Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by neuronal damage, amyloid plaque deposition, and chronic inflammation in the central nervous system (CNS). ...
The Role of Microglia in Neuroinflammation: Metabolic and Gender Differences in Aging Research Background Aging is a major risk factor for neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease. Even healthy aging is accompanied by a decline in cognitive function. Previous research has indicated that microglia undergo s...
Co-localization of Gangliosides with Amyloid Beta Plaques in Alzheimer’s Disease Detected by MALDI-MSI and Histology Alzheimer’s Disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment and behavioral changes. Historically, AD research has focused on misfolded proteins, but with advancements in mass spectrometry...