A Microbial Metabolite Inhibits the HIF-2α-Ceramide Pathway to Mediate the Beneficial Effects of Time-Restricted Feeding on MASH

Medicine, Hepatobiliary System, Basic Medical Sciences, Life Sciences, Biochemistry, Microbiology,
Microbial Metabolite   Time-Restricted Feeding   HIF-2α   Ceramide   MASH   MASLD   Ruminococcus Torques  

A Microbial Metabolite Mediates the Beneficial Effects of Time-Restricted Feeding on MASH by Inhibiting the HIF-2A-Ceramide Pathway Introduction Background: Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH) is a major health problem affecting a quarter of the global population. MA...

Diabetic Retinopathy is a Ceramidopathy Reversible by Anti-Ceramide Immunotherapy

Medicine, Ophthalmology, Life Sciences, Biochemistry, Immunology,
Diabetic Retinopathy   Ceramide   Immunotherapy   Endothelial Cells   Metabolic Disorder  

Diabetic Retinopathy as a Ceramide Disease Reversible by Anti-Ceramide Immunotherapy Background Diabetic Retinopathy (DR) is one of the most common metabolic disorders worldwide. Diabetes not only leads to chronic complications in macrovascular and microvascular systems but also imposes significant socio-economic burdens. As a microvascular complic...