Intermittent Hypoxia Exacerbates Anxiety in High-fat Diet-Induced Diabetic Mice by Inhibiting TREM2-Regulated IFNAR1 Signaling

Medicine, Respiratory System, Psychiatry, Endocrinology, Neurology,
Type 2 Diabetes Mellitus   Obstructive Sleep Apnea   Anxiety   Microglia   TREM2   IFNAR1   Cognition  

Over the past few decades, the incidence of type 2 diabetes mellitus (T2DM) has been on the rise, becoming a global public health issue. T2DM not only affects patients’ metabolic levels but also has profound impacts on cognitive function and mental health. Studies have shown that patients with T2DM exhibit brain structural abnormalities, a decline ...

Transient Brain Structure Changes After High Phenylalanine Exposure in Adults with Phenylketonuria

Medicine, Pediatrics, Neurology, Medical Imaging,
Phenylketonuria   Surface-based morphometry   Cognition   Intervention   Randomized controlled trial   Recovery  

The Impact of High Phenylalanine Exposure on Brain Structure in Adult Phenylketonuria Patients Background Phenylketonuria (PKU) is a rare hereditary metabolic disorder characterized by a deficiency of phenylalanine hydroxylase, leading to elevated levels of phenylalanine (Phe) in the blood and brain. If Phe levels are not strictly controlled during...