Selective Advantage of Mutant Stem Cells in Human Clonal Hematopoiesis Associated with Attenuated Response to Inflammation and Aging

Medicine, Hematology, Life Sciences, Biochemistry, Immunology, Genetics,
mutant stem cells   clonal hematopoiesis   inflammation   aging   selective advantage   DNMT3A mutation   TET2 mutation  

Selective Advantage of Clonal Hematopoietic Mutant Stem Cells in Aging and Inflammatory Responses Background and Research Motivation Clonal Hematopoiesis (CH) is an aging-related phenomenon in the hematopoietic system, where hematopoietic stem cells (HSCs) acquire specific somatic mutations and undergo expansion, causing a particular mutated cell l...