Not Fleeting but Lasting: Limited Influence of Aging on Implicit Adaptive Motor Learning and its Short-Term Retention

The Impact of Aging on Implicit Motor Learning and Short-term Memory: A Study Based on Force Field Adaptation Research Background Motor adaptation is the process by which the brain adjusts motor strategies in response to environmental changes, typically involving two mechanisms: explicit learning and implicit learning. Explicit learning is a rapid,...

Achieving Healthy Aging Through Gut Microbiota-Directed Dietary Intervention: Focusing on Microbial Biomarkers and Host Mechanisms

Achieving Healthy Aging through Gut Microbiota-Directed Dietary Intervention: Focusing on Microbial Biomarkers and Host Mechanisms Academic Background With the intensification of global population aging, preventing age-related diseases and extending healthy life expectancy have become critical issues in global public health. Gut microbiota has been...

Surface Structural Changes in Silicone Rubber Due to Electrical Tracking

Cutting-Edge Scientific News: Research Reveals Degradation Mechanisms of Silicone Rubber under Electrical Tracking Background: Motivation and Challenges With the rapid development of power transmission and distribution systems, polymer composite insulators have gradually replaced traditional glass and ceramic insulators as the preferred materials f...

Recovery from Spreading Depolarization is Slowed by Aging and Accelerated by Antioxidant Treatment in Locusts

The Impact of Aging and Antioxidants on the Recovery from Spreading Depolarization in Locusts Academic Background Spreading Depolarization (SD) is a phenomenon that temporarily shuts down neural processing in both mammals and insects. In humans, SD is associated with various pathological states, such as migraine aura and neuronal death following tr...

Choroid Plexus Aging: Structural and Vascular Insights from the HCP-Aging Dataset

Research on Choroid Plexus Aging and Cerebrospinal Fluid Dynamics Background Introduction The choroid plexus (CHP) is a highly vascularized structure located within the brain ventricles, primarily responsible for the production of cerebrospinal fluid (CSF) and the clearance of metabolic waste. It plays a crucial role in maintaining neurofluid homeo...

Mechanisms of Age-Associated Variation in Immune Cell Regeneration Across Individuals

The functional decline of the immune system with aging is characterized by an increase in innate immune cells (e.g., granulocytes) and a decrease in adaptive immune cells (e.g., B cells). This imbalance in the immune system is closely related to the onset of various diseases, particularly myeloid leukemia and immune deficiencies common in the elder...

Selective Advantage of Mutant Stem Cells in Human Clonal Hematopoiesis Associated with Attenuated Response to Inflammation and Aging

Selective Advantage of Clonal Hematopoietic Mutant Stem Cells in Aging and Inflammatory Responses Background and Research Motivation Clonal Hematopoiesis (CH) is an aging-related phenomenon in the hematopoietic system, where hematopoietic stem cells (HSCs) acquire specific somatic mutations and undergo expansion, causing a particular mutated cell l...

Role of SDHAF1 in Aging Hematopoietic Stem Cells: Enhancing Metabolic Resilience through Mitochondrial ATP Production

Role of SDHAF1 in Aging Hematopoietic Stem Cells: Enhancing Metabolic Resilience through Mitochondrial ATP Production

Research Background and Objective As individuals age, hematopoietic stem cells (HSCs) progressively accumulate in the bone marrow, exhibiting metabolic resilience under various stress conditions. This metabolic resilience provides an aging advantage for HSCs, enabling them to maintain cell viability even under low metabolic conditions. Although agi...

Aging-induced tRNAglu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

Aging-induced trnaGlu-derived fragments disrupt glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization Academic Background Mitochondrial cristae are inward protrusions of the inner mitochondrial membrane that undergo significant morphological changes during aging. However, the molecular mechanisms leading to th...

Effects of Chronic Hypertension on the Energy Metabolism of Cerebral Cortex Mitochondria in Normotensive and Spontaneously Hypertensive Rats During Aging

Effects of Chronic Hypertension on Mitochondrial Energy Metabolism in the Cerebral Cortex of Normal and Spontaneously Hypertensive Rats Background Introduction Chronic hypertension has destructive structural and functional consequences for cerebral vessels and brain parenchyma. Hypertension impairs cerebrovascular autoregulation (Ferrari & Villa, 2...