Selective Advantage of Mutant Stem Cells in Human Clonal Hematopoiesis Associated with Attenuated Response to Inflammation and Aging

Medicine, Hematology, Life Sciences, Biochemistry, Immunology, Genetics,
mutant stem cells   clonal hematopoiesis   inflammation   aging   selective advantage   DNMT3A mutation   TET2 mutation  

Selective Advantage of Clonal Hematopoietic Mutant Stem Cells in Aging and Inflammatory Responses Background and Research Motivation Clonal Hematopoiesis (CH) is an aging-related phenomenon in the hematopoietic system, where hematopoietic stem cells (HSCs) acquire specific somatic mutations and undergo expansion, causing a particular mutated cell l...

Clonal Hematopoiesis in Patients with Neuroendocrine Tumor Treated with Lutetium-177 and the Risk of Thrombocytopenia: A Prospective Study

Clonal Hematopoiesis in Patients with Neuroendocrine Tumor Treated with Lutetium-177 and the Risk of Thrombocytopenia: A Prospective Study

Medicine, Endocrinology, Hematology, Oncology,
clonal hematopoiesis   neuroendocrine tumor   thrombocytopenia   lutetium-177   radionuclide therapy   myeloid neoplasm   genetic mutations  

Clonal Hematopoiesis and Risk of Thrombocytopenia in Neuroendocrine Tumor Patients Undergoing 177Lu Therapy: A Prospective Study Background and Research Motivation The incidence of Neuroendocrine Tumors (NETs) has gradually increased in recent years. Prognosis depends on various factors such as the location of the primary tumor, disease grading, st...

Identification of Clonal Hematopoiesis Driver Mutations Through In Silico Saturation Mutagenesis

Information Science, Computer Science, Artificial Intelligence, Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Immunology, Genetics,
clonal hematopoiesis   driver mutations   in silico saturation mutagenesis   machine learning models   oncology  

Introduction In the process of healthy hematopoiesis, a group of hematopoietic stem cells (HSC) contribute to all blood-related lineages. However, as we age, this process often leads to clonal hematopoiesis (CH), meaning the expansion of clones originating from a particular HSC, which then occupies a significant portion of blood cells and platelets...

CRISPR dependency screens in primary hematopoietic stem cells identify KDM3B as a genotype-specific vulnerability in IDH2- and TET2-mutant cells

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry,
hematopoietic stem cells   KDM3B   epigenetics   clonal hematopoiesis   CRISPR screens   acute myeloid leukemia  

CRISPR-Dependent Screening in Primary Hematopoietic Stem Cells Identifies KDM3B as Specific Susceptibility for IDH2 and TET2 Mutant Genotypes Background and Significance Clonal Hematopoiesis (CH) refers to the abnormal growth of genetically distinct subclones of cells initiated by specific mutations in Hematopoietic Stem Cells (HSCs). This phenomen...