Synaptic Targets and Cellular Sources of CB1 Cannabinoid Receptor and Vesicular Glutamate Transporter-3 Expressing Nerve Terminals in Relation to GABAergic Neurons in the Human Cerebral Cortex

Medicine, Neurology, Life Sciences,
CB1 receptor   GABAergic neurons   vesicular glutamate transporter   synaptic transmission   cerebral cortex  

Distribution and Function of CB1 Cannabinoid Receptor and VGLUT3 in the Human Cerebral Cortex Background Cannabinoid receptor 1 (CB1) regulates synaptic transmission through presynaptic receptors in nerve terminals, and its physiological roles are of significant clinical relevance. However, the cellular sources and synaptic targets of CB1-expressin...

GABAergic Neuronal Lineage Development Determines Clinically Actionable Targets in Diffuse Hemispheric Glioma

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
GABAergic neurons   lineage development   diffuse hemispheric glioma   H3G34 mutation   CDK6   tumor therapy  

Background and Research Objectives High-Grade Glioma (HGG) is a highly lethal primary brain tumor with a particularly high incidence and mortality rate in children and adolescents. HGG can be further divided into several subtypes, among which Diffuse Hemispheric Glioma, H3G34-mutant (DHG-H3G34), is a rare subtype with poor prognosis, mainly occurri...

Cortico-cortical transfer of socially derived information gates emotion recognition

Medicine, Neurology, Life Sciences, Biophysics, Humanities and Others,
social cognition   emotion recognition   cortical network   GABAergic neurons   psychiatric disorders   mouse models   functional imaging  

The Gating Role of Cortical Transfer of Socially Derived Information in Emotion Recognition Background Introduction Emotion recognition and the subsequent responses are crucial for survival and maintaining social functions. However, how social information is processed to reliably recognize emotions remains unclear. In this new study, the authors re...