Alternative Lengthening of Telomere-Based Immortalization Renders H3G34R-Mutant Diffuse Hemispheric Glioma Hypersensitive to PARP Inhibitor Combination Regimens

Medicine, Neurology, Oncology,
alternative lengthening of telomeres   H3G34R mutation   diffuse hemispheric glioma   PARP inhibitors   DNA damage stress  

Background Introduction Diffuse Hemispheric Glioma (DHG) is a highly aggressive and poorly prognostic high-grade glioma, particularly prevalent in children and adolescents. The H3G34R/V mutation is one of the common genetic alterations in this type of tumor, often accompanied by the inactivation of the ATRX (Alpha-Thalassemia/Mental Retardation Syn...

GABAergic Neuronal Lineage Development Determines Clinically Actionable Targets in Diffuse Hemispheric Glioma

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
GABAergic neurons   lineage development   diffuse hemispheric glioma   H3G34 mutation   CDK6   tumor therapy  

Background and Research Objectives High-Grade Glioma (HGG) is a highly lethal primary brain tumor with a particularly high incidence and mortality rate in children and adolescents. HGG can be further divided into several subtypes, among which Diffuse Hemispheric Glioma, H3G34-mutant (DHG-H3G34), is a rare subtype with poor prognosis, mainly occurri...