Aging-Induced MCPH1 Translocation Activates Necroptosis and Impairs Hematopoietic Stem Cell Function

Medicine, Medical Laboratory Science, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry,
Aging   MCPH1   Necroptosis   Hematopoietic Stem Cells   DNA Damage   Nuclear Translocation   Gene Function  

Study on MCPH1 Nuclear Transfer Induced by Aging Activating Necrosis and Impairing Hematopoietic Stem Cell Function Research Background The aging of hematopoietic stem cells is associated with an increased risk of various blood diseases, and DNA damage is a significant factor driving the aging of hematopoietic stem cells. However, the underlying mo...