Chaperone- and PTM-mediated Activation of IRF1 Tames Radiation-induced Cell Death and the Inflammatory Response

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Interferon Regulatory Factor 1   Ionizing Radiation   Nuclear Translocation   Posttranslational Modification   Transcription Regulation  

Study on IRF1 Transcriptional Activation Regulation of Radiation-Induced Cell Death and Inflammatory Response under Mutagenic Stress Background Recent multi-omics studies have revealed the key role of structural cells in immune regulation, but the mechanism remains unclear. Based on this, this study mainly explores how the transcriptional activatio...

Aging-Induced MCPH1 Translocation Activates Necroptosis and Impairs Hematopoietic Stem Cell Function

Medicine, Medical Laboratory Science, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry,
Aging   MCPH1   Necroptosis   Hematopoietic Stem Cells   DNA Damage   Nuclear Translocation   Gene Function  

Study on MCPH1 Nuclear Transfer Induced by Aging Activating Necrosis and Impairing Hematopoietic Stem Cell Function Research Background The aging of hematopoietic stem cells is associated with an increased risk of various blood diseases, and DNA damage is a significant factor driving the aging of hematopoietic stem cells. However, the underlying mo...