Nanoligomers Targeting NF-κB and NLRP3 Reduce Neuroinflammation and Improve Cognitive Function with Aging and Tauopathy

Chemistry, Nanoscience, Medicine, Geriatrics, Neurology, Life Sciences, Bioengineering,
NF-κB   NLRP3   Neuroinflammation   Aging   Tauopathy   Cognitive Function  

Nanopolymer Targeting NF-κB and NLRP3 Reduces Neuroinflammation and Enhances Cognitive Function in Aging and Tauopathy Research Background Aging is a major risk factor for cognitive decline and most neurodegenerative diseases, such as Alzheimer’s disease (AD). These cognitive declines are closely related to the pathological aggregation of Tau prote...

Characterisation of Premature Cell Senescence in Alzheimer’s Disease Using Single Nuclear Transcriptomics

Characterisation of Premature Cell Senescence in Alzheimer’s Disease Using Single Nuclear Transcriptomics

Medicine, Basic Medical Sciences, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry,
Aging   Senescence   Glia   Alzheimer’s Disease   Single Cell Transcriptomics   Image Mass Cytometry   Senolytics  

Characteristics of Premature Cellular Senescence in Alzheimer’s Disease: Application of Single-Nucleus Transcriptomics Research Background and Objectives Alzheimer’s disease (AD) is the most common type of dementia in the elderly, characterized by extracellular deposition of β-amyloid protein and intracellular neurofibrillary tangles. Other patholo...

Aging-Induced MCPH1 Translocation Activates Necroptosis and Impairs Hematopoietic Stem Cell Function

Medicine, Medical Laboratory Science, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry,
Aging   MCPH1   Necroptosis   Hematopoietic Stem Cells   DNA Damage   Nuclear Translocation   Gene Function  

Study on MCPH1 Nuclear Transfer Induced by Aging Activating Necrosis and Impairing Hematopoietic Stem Cell Function Research Background The aging of hematopoietic stem cells is associated with an increased risk of various blood diseases, and DNA damage is a significant factor driving the aging of hematopoietic stem cells. However, the underlying mo...

Targeting Dysregulated Phago-/Auto-Lysosomes in Sertoli Cells to Ameliorate Late-Onset Hypogonadism

Medicine, Basic Medical Sciences, Medical Laboratory Science, Geriatrics, Urology, Life Sciences, Biochemistry,
Late-Onset Hypogonadism   Sertoli Cells   Lysosomes   Aging   Single-Cell RNA Sequencing   Lipid Metabolism   Inflammation  

Research Background This study focuses on late-onset hypogonadism (LOH), aiming to uncover the mechanisms associated with age-related testicular function deviations, such as LOH, which are not yet fully understood. Utilizing single-cell RNA sequencing technology, the study analyzed the testicles of humans with LOH to identify supporting cells (SCs)...

Age-dependent Loss of Hapln1 Erodes Vascular Integrity via Indirect Upregulation of Endothelial ICAM1 in Melanoma

Medicine, Medical Laboratory Science, Geriatrics, Oncology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Immunology,
Hapln1   Melanoma   Vascular Integrity   ICAM1   Aging   Extracellular Matrix  

Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma In a research article titled “Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma” published in Nature Aging in March 2024, significant findings have been revealed. The study...

Age-Related Changes in the Susceptibility to Visual Illusions of Size

Medicine, Geriatrics, Neurology,
Visual Perception   Aging   Visual Illusions   Size Perception  

As the global population ages, understanding the impact of aging on visual perception becomes increasingly important. This study investigates age-related changes in size perception in adults through three visual illusions: the Ponzo illusion, the Ebbinghaus illusion, and the height-width illusion. Based on a Bayesian model that conceptualizes the a...