Cascading Pattern in Genetic Risk Research for Alzheimer’s Disease Background and Research Motivation Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder characterized by the accumulation of two pathological features: amyloid plaques and phosphorylated tau neurofibrillary tangles. These pathological features typically exist ...
Intermittent Clearance of High p21-Expressing Cells Extends Lifespan and Delivers Sustained Health Benefits Research Background With the significant extension of human lifespan, the global elderly population is rapidly increasing. Elderly individuals often face decreased functionality and various chronic diseases in their later years, such as cardi...
Study on the Long-Term Risk of Dementia in Parkinson’s Disease Background Parkinson’s Disease (PD) is a common neurodegenerative disorder primarily characterized by motor dysfunction. However, cognitive decline and Parkinson’s disease dementia (PDD) are also significant non-motor symptoms of PD. Although dementia occurs in approximately 80% of PD p...
Alzheimer’s Disease (AD) and Microbleeds in Down Syndrome (DS) Populations: Their Localization and Association with Imaging and Cerebrospinal Fluid (CSF) Biomarkers This study was conducted by a team led by Sara E. Zsadanyi and Alejandra O. Morcillo-Nieto, with contributors including Mateus R. Aranha, José E. Arriola-Infante, Lídia Vaqué-Alcázar,...
Research Report on Progressive Multidimensional Clinical and Radiological Variations in Patients with Alzheimer’s Disease and Posterior Cortical Atrophy Background Introduction Alzheimer’s Disease (AD) has multiple phenotypes, including the typical amnestic and non-amnestic (atypical) phenotypes. Posterior Cortical Atrophy (PCA) is a prominent atyp...
Study on the Association# Study on the Association Between Body Composition Patterns, Cardiovascular Diseases Between, Body and Neurodegenerative Composition Disease Risks Background Neurodegenerative Patterns diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease, (PD), currently affect over Cardiovascular Diseases, and Neuro60degene...
EEG-Guided Anesthesia and Delirium in Elderly Patients After Cardiac Surgery Research Background Delirium is a common postoperative complication in elderly patients, particularly after cardiac surgery. Delirium not only leads to cognitive decline but also increases hospitalization time and medical costs. Current preventive measures are limited in e...
Association Between Milestone Ratings and Certification Exam Scores of Medical Residents and Patient Outcomes Background In the United States, the education and competency assessment of internal medicine residents are primarily conducted through two methods: the Milestone assessment system and the American Board of Internal Medicine (ABIM) certific...
A scientific paper authored by Ricardo Augusto Leoni de Sousa and his research team was published in Volume 26, Issue 31 of the journal “Neuromolecular Medicine” in 2024. The paper is titled “Physical exercise inhibits cognitive impairment and memory loss in aged mice, and enhances pre- and post-synaptic proteins in the hippocampus of young and age...
Effects of Chronic Hypertension on Mitochondrial Energy Metabolism in the Cerebral Cortex of Normal and Spontaneously Hypertensive Rats Background Introduction Chronic hypertension has destructive structural and functional consequences for cerebral vessels and brain parenchyma. Hypertension impairs cerebrovascular autoregulation (Ferrari & Villa, 2...